Kid-Key-Lock is a simple program to selectively lock specific keyboard and mouse functions. You can use kid-key-lock to lock any of the mouse buttons, double clicks and/or the mouse wheel. Regarding the keyboard, Kid-Key-Lock can be used to lock character keys, navigation keys, function keys and/or system shortcuts (such as Alt-F4, Alt-Tab, "Start" key, etc).

Screenshot of KidKeyLock